Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing.
BACKGROUND: Atrial fibrillation (AF) is characterized by electrical and structural remodeling. Irregular and / or rapid atrio-ventricular (AV) conduction during AF can result in AV dyssynchrony, tachymyopathy, pressure and volume overload with Rabbit Clia Kits subsequent dilatation, valve regurgitation, ventricular dysfunction and heart failure progresses. Objective : To gain further insight into the pathophysiology of myocardial changes caused by tachypacing right atrium (A-TP) in a large animal model. Methods: A total of 28 pigs Landrace randomly as 14 to AF-induced group A-TP and 14 pigs for the control group. AF tachypaced pigs for 43 ± 4 days up in sustained AF. functional renovation investigated by echocardiography (after cardioversion to sinus rhythm). structural renovation was quantified by histological preparations with picrosirius red and immunohistochemical staining. Results: A-TP resulted in decreased left ventricular ejection fraction (LVEF) is accompanied ...