BACKGROUND: Atrial fibrillation (AF) is characterized by electrical and structural remodeling. Irregular and / or rapid atrio-ventricular (AV) conduction during AF can result in AV dyssynchrony, tachymyopathy, pressure and volume overload with Rabbit Clia Kits subsequent dilatation, valve regurgitation, ventricular dysfunction and heart failure progresses. Objective : To gain further insight into the pathophysiology of myocardial changes caused by tachypacing right atrium (A-TP) in a large animal model. Methods: A total of 28 pigs Landrace randomly as 14 to AF-induced group A-TP and 14 pigs for the control group. AF tachypaced pigs for 43 ± 4 days up in sustained AF. functional renovation investigated by echocardiography (after cardioversion to sinus rhythm). structural renovation was quantified by histological preparations with picrosirius red and immunohistochemical staining. Results: A-TP resulted in decreased left ventricular ejection fraction (LVEF) is accompanied ...
This study aims to present a new method to develop a pig model of portal vein thrombosis (PVT) in cirrhosis with intravenous administration of thrombin and the insertion of a fibered coils. We further investigated changes in biochemical parameters, coagulation, and Simian Clia Kits the expression of proinflammatory cytokines in the group of cirrhosis-PVP. method Twelve male pigs were randomized into a control group (n = 3) and cirrhosis group (n = 9). In pigs cirrhosis, three randomly selected to build PVP with ultrasound-guided percutaneous puncture of the main portal vein (MPV) followed by administration of intravenous thrombin and fibered coil insertion. Thrombosis in MPV is detected by enhanced abdominal computed tomography (CT). Changes in liver function, coagulation system, and inflammatory cytokines compared between normal, cirrhosis, and cirrhosis with groups PVT. As manifested by the presence of MPV filling defects in the portal venous-phase CT angiography, fibrin thro...