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A Preclinical Porcine Model of Portal Vein Thrombosis in Liver Cirrhosis.

This study aims to present a new method to develop a pig model of portal vein thrombosis (PVT) in cirrhosis with intravenous administration of thrombin and the insertion of a fibered coils. We further investigated changes in biochemical parameters, coagulation, and Simian Clia Kits the expression of proinflammatory cytokines in the group of cirrhosis-PVP.
method
Twelve male pigs were randomized into a control group (n = 3) and cirrhosis group (n = 9). In pigs cirrhosis, three randomly selected to build PVP with ultrasound-guided percutaneous puncture of the main portal vein (MPV) followed by administration of intravenous thrombin and fibered coil insertion. Thrombosis in MPV is detected by enhanced abdominal computed tomography (CT). Changes in liver function, coagulation system, and inflammatory cytokines compared between normal, cirrhosis, and cirrhosis with groups PVT.
As manifested by the presence of MPV filling defects in the portal venous-phase CT angiography, fibrin thrombus forms in the MPV in pigs cirrhosis within a week and last for four weeks. Five weeks after surgery, abnormal liver function occur in connection with the formation of PVP in cirrhosis. Both coagulation and thromboelastography parameters indicate that swine cirrhosis-PVP exhibited procoagulant state through hyperfunction of platelets and clotting factors. Interleukin 6 (IL-6) as a potential marker of inflammation stimulate the activation of the PVP-mediated inflammation in cirrhosis.
conclusion
Our study provides in vivo evidence that intravenous injection of thrombin into a coil and MPV under guided intervention device allows a method in the creation of thrombus. exploration and validation of large sample case more information is needed to characterize the utility of this model.
A Preclinical Porcine Model of Portal Vein Thrombosis in Liver Cirrhosis.

mechanical changes in the avascular region of the meniscus following partial meniscectomy: An elongated pig cadaver meniscal tear model.


Although partial meniscectomy is a common treatment for tears in the avascular region of the meniscus, the following mechanical changes meniscectomy known to initiate mechanical induced osteoarthritis. We aim to measure contact pressure distribution articular cartilage in the knee surgically repaired and partially resected menisci in avascular region.

A pneumatic loading device developed to implement the 1000 N compressive load on sample pig cadaver knee in flexion angles of 20, 35, 50, and 65 °. We simulated longitudinal meniscal tears in the avascular portion and the third inner well-vascularization 1/3 central part of the meniscus. Articular cartilage contact pressure on the knee with intact, ripped, repaired, https://gentaur.cz/ and resected menisci tears that compared.For well-vascularization in the area, contact pressure is restored meniscal repair articular cartilage in the joints to level intact. 

However, partial meniscectomy significantly increases the maximum contact pressure and the contact pressure of the average in the area is very congested. However, partial meniscectomy in avascular region do not change the contact pressure of the articular cartilage maximum and average contact pressure in the area is very congested.
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